星形细胞肿瘤中微卫星DNA不稳定性的出现及其频率取决于肿瘤的恶性程度。恶性程度高的星形细胞肿瘤常可检出MSI,且伴有错配修复基因的突变率也较高。某些MSI位点可作为间变性星形细胞瘤预后的一个指征。由于某些错配修复基因的缺陷导致微卫星DNA不稳定性 ,基因组不稳定性的影响在星形细胞肿瘤的发生、发展过程中具有重要意义 The frequency and frequency of microsatellite DNA instability in astrocytic tumors depends on the degree of malignancy of the tumor. Malignant astrocyte tumors can often detect MSI, and the mutation rate associated with mismatch repair genes is also high. Certain MSI loci serve as an indication of the prognosis of anaplastic astrocytomas. Due to the defects of certain mismatch repair genes that cause microsatellite DNA instability, the effects of genomic instability have important implications in the development and progression of astrocytic tumors.