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目的探讨早期类风湿关节炎患者中抗环瓜氨酸肽抗体(抗CCP抗体)与关节破坏程度的相关性。方法观察64例CCP阳性与58例CCP阴性的早期类风湿关节炎患者双手X线变化,分别于就诊1年后、2年后行双手X检查,比较两组间的差异。结果抗CCP阳性者与阴性组的X线在初诊及随诊后1年比较差异无统计学意义,随诊2年后两组的X线分期变化比较差异统计学意义。结论抗CCP抗体与X线提示的RA骨破坏有相关性。
Objective To investigate the relationship between anti-cyclic citrullinated peptide antibody (anti-CCP antibody) and the degree of joint destruction in patients with early-stage rheumatoid arthritis. Methods Two-hand X-ray findings of 64 cases of CCP positive and 58 cases of CCP negative early rheumatoid arthritis were observed. Two years after the first year of treatment and two-hand X-ray examination, the differences between the two groups were compared. Results There was no significant difference in X-ray between anti-CCP positive group and negative group at first visit and one year after follow-up. Two years after follow-up, X-ray staging showed significant difference. Conclusion The anti-CCP antibody is correlated with the destruction of RA bone by X-ray.