蛋白激酶C(PKC)是丝氨酸/苏氨酸蛋白激酶家族中的主要成员,至少有12种同功酶。PKC能被多种激素、生长因子、神经递质激活,参与细胞生长分化、神经传导、基因表达调节及肿瘤生长转移等生理病理过程。本文叙述了PKC活化在肾脏生长发育中的作用及其与遗传性肾病、原发性和继发性肾脏疾病之间的关系,以及PKC抑制剂的应用前景。 Protein kinase C (PKC) is a major member of the serine / threonine protein kinase family with at least 12 isozymes. PKC can be activated by a variety of hormones, growth factors and neurotransmitters and is involved in the physiological and pathological processes such as cell growth and differentiation, nerve conduction, gene expression regulation and tumor growth and metastasis. This article describes the role of PKC activation in renal growth and development and its relationship with hereditary nephropathy, primary and secondary kidney disease, and the potential of PKC inhibitors.