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胰岛移植治疗胰岛素依赖型糖尿病,其疗效不够满意的主要原因是:受者产生排异反应及移植的是胰腺组织碎片而非纯化胰岛。 重庆医科大学人工细胞研究室舒昌达教授等在糖尿病小鼠腹腔内移植免疫隔离膜包裹大鼠胰岛(中华内分泌代谢杂志(1991;7(2):101)工作的基础上;发现微囊包膜猪胰岛在体外培养时,能稳定地分泌胰岛素,故将微囊包膜纯化初生猪胰岛移植至糖尿病大鼠腹腔内,进行异种胰岛移植研究。
Islet transplantation for the treatment of insulin-dependent diabetes mellitus, the effect is not satisfied with the main reason is: the recipient rejection and transplantation of pancreatic tissue fragments instead of purified islets. Based on the work of intraperitoneal transplantation of immunoisolecules in rat islets isolated from diabetic mice (Journal of Endocrinology and Metabolism (1991; 7 (2): 101), Professor Shu Changda, an artificial cell research laboratory of Chongqing Medical University, found that microencapsulated pigs Islet cultured in vitro, stable secretion of insulin, so the microencapsulated purified porcine islet transplantation into diabetic rat abdominal cavity, islet xenograft study.