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目的 :探讨粘附分子在脑梗塞不同时期含量变化作用机理以及临床意义。方法 :利用酶联免疫吸附法 (ELISA)分别监测脑梗塞急性期、恢复期可溶性细胞间粘附分子 1(sICAM 1)、E 选择素 (sE se lectin)血清含量。结果 :脑梗塞急性期sICAM 1、sE selectin含量明显升高 ,与恢复期及对照组比较有显著差异 (P <0 .0 5 ) ,sICAM 1、、sE selectin二者含量显著相关 (P <0 .0 5 )。结论 :粘附分子sICAM 1、、sE selectin共同介导了白细胞的滚动浸润 ,参与了脑梗塞急性期的炎症损伤。
Objective: To investigate the mechanism and clinical significance of the changes of adhesion molecules in different stages of cerebral infarction. Methods: Serum levels of soluble intercellular adhesion molecule 1 (sICAM 1) and e-selectin (sE se lectin) were detected by enzyme-linked immunosorbent assay (ELISA) Results: The levels of sICAM 1 and sE selectin were significantly increased in the acute stage of cerebral infarction (P <0.05), sICAM 1 and sE selectin were significantly correlated with those in recovery and control groups (P <0. 05) .0 5). Conclusion: The adhesion molecules sICAM1, sE selectin mediate the rolling infiltration of leukocytes and participate in the inflammatory injury in the acute stage of cerebral infarction.