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目的 探讨中耳加压治疗是否可抑制豚鼠内淋巴积水。方法 4 2只豚鼠随机分为 4组 :对照组 10只 ,双耳未手术 ;32只豚鼠右耳制备内淋巴积水的动物模型 :积水 4周组 10只 ,积水 8周组 10只 ,加压组 12只。加压组豚鼠在术后第 5周起在压力舱内进行加压治疗 ,共 3周。观察 4组动物耳蜗形态和功能的变化。结果 加压组右耳 70 d B SPL - SP/ AP值、最大中阶面积 (SMA )比率 (分别 0 .2 9±0 .0 9,2 .2 3± 0 .2 0 )与相同生存期的积水 8周组 (分别为 0 .6 9± 0 .15 ,4 .0 1± 0 .5 2 )相比显著减小 (P<0 .0 5 ) ,而与积水 4周组 (分别为 0 .2 9± 0 .13,2 .2 2± 0 .2 0 )差异不显著 (P>0 .0 5 )。加压组右耳听觉脑干电反应 (ABR)听阈 [(36 .6 7± 14 .30 ) d B SPL ]低于积水 8周组 [(44 .0 0± 14 .30 ) d B SPL ],但差别无统计学意义 (P>0 .0 5 )。结论 加压治疗可显著抑制内淋巴积水的发展 ,并改善耳蜗功能。为梅尼埃病的治疗寻找一种无创伤性方法——加压治疗提供实验依据。
Objective To investigate if middle ear compression therapy can inhibit guinea pig endolymphatic hydrops. Methods 4 2 guinea pigs were randomly divided into 4 groups: control group of 10, both ears without surgery; 32 guinea pigs in the right ear preparation of endolymphatic hydrops animal model: water 4 weeks group 10, water 8 weeks group 10 , Pressure group 12 only. Guinea pigs in the pressure group were pressure-treated in the pressure chamber at the 5th week after the operation for 3 weeks. The morphology and function of the cochlea in four groups were observed. Results Compared with the control group, the SPL - SP / AP value at 70 d of the right ear and the maximal mid - step area (SMA) ratio (0.29 ± 0.09, 2.23 ± 0.2, respectively) (P <0.05) in the 8-week hydrocephalus group (0.96 ± 0.15, 4.01 ± 0.52, P <0.05) Respectively, 0.29 ± 0.13, 2.22 ± 0.2, respectively) (P> 0.05). The hearing threshold of the right ear auditory brainstem response (ABR) in the pressurized group [(36.67 ± 14.30) d B SPL] was lower than that in the 8-week water-sparing group [(44.0 ± 14.30) d B SPL ], But the difference was not statistically significant (P> 0.05). Conclusion Pressure treatment can significantly inhibit the development of endolymphatic hydrops and improve the cochlear function. Find a non-invasive method for the treatment of Meniere’s disease - pressure-based treatment to provide experimental evidence.