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目的：探讨血浆胱抑素C(Cystatin C，CysC)水平对2型糖尿病肾病早期诊断中的临床价值。方法120例住院患者根据尿白蛋白排泄率(UAER)分为两组，单纯糖尿病组(单纯组)；早期糖尿病肾病组(早期肾病组)，同期60例门诊健康体检者为(对照组)。入组时常规检测常规生化指标外，同时用乳胶颗粒增强免疫比浊法检测CysC血浆水平。结果单纯组及早期肾病组CysC水平显著高于对照组(<0.05),早期肾病组显著高于单纯组。早期肾病组的高CysC患者百分数较单纯组显著增加(P<0.05)。结论高CysC可作为糖尿病肾病的早期诊断指标之一，也可能为临床治疗效果的评估指标。“,”Objective To investigate the correlation of serum cystatin C (Cystatin C CysC) on the level of clinical value in the early diagnosis of type 2 diabetic nephropathy. Methods 120 patients with urinary albumin excretion rate (UAER) were divided into 2 groups, group A (simple group); the early diabetic nephropathy group (early group) and healthy subjects served (the control group). The group of conventional routine biochemical tests, at the same time using latex particle enhanced immune detection of plasma levels of CysC turbidity method. Results The simple group and early group CysC was significantly higher than that of the control group ( < 0.05), early kidney disease group were significantly higher than that group. Early group CysC patients with high percentage than simple group significantly ( < 0.05). Conclusion CysC can be used as a marker for early diagnosis of diabetic nephropathy, may the evaluation index for the clinical treatment.