【摘 要】
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Tumorigenicity-inhibiting compounds have been identified in our daily diet.For example,isothiocyanates (ITCs) found in cruciferous vegetables were reported to have potent cancer-prevention activities.The best characterized ITC is sulforaphane (SF).SF can
【机 构】
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McGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dentistry, McGill Unive
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Tumorigenicity-inhibiting compounds have been identified in our daily diet.For example,isothiocyanates (ITCs) found in cruciferous vegetables were reported to have potent cancer-prevention activities.The best characterized ITC is sulforaphane (SF).SF can simultaneously modulate multiple cellular targets involved in carcinogenesis,including (1) modulating carcinogen-metabolizing enzymes and blocking the action of mutagens;(2) inhibition of cell proliferation and induction of apoptosis;and (3) inhibition of neo-angiogenesis and metastasis.SF targets cancer stem cells through modulation of nuclear factor kappa B (NF-κB),Sonic hedgehog (SHH),epithelial-mesenchymal transition,and Wnt/β-catenin pathways.Conventional chemotherapy/SF combination was tested in several studies and resulted in favorable outcomes.With its favorable toxicological profile,SF is a promising agent in cancer prevention and/or therapy.In this article,we discuss the human metabolism of SF and its effects on cancer prevention,treatment,and targeting cancer stem cells,as well as providing a brief review of recent human clinical trials on SF.
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