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目的:优选黄连解毒汤药效物质提取时方药最佳组合方式。方法:将方药排列组合成15组,用半仿生提取法提取;以小檗碱、黄芩素、栀子苷、总生物碱、总黄酮、HPLC总面积、≤1 000提取物为指标,将各指标测得值进行标准化处理,并经加权求和后得综合评价Y值,Y值大者为优。结果:7个指标综合评价Y值以AD+BC最大。结论:黄连解毒汤的提取,以黄连和栀子、黄芩和黄柏分别合提,再将提取液合并为最佳。
OBJECTIVE: To optimize the optimal combination of herbs for the extraction of pharmacodynamic substances of Coptis chinensis. METHODS: The herbs were arranged in 15 groups and extracted by semi-bionic extraction. The contents of berberine, baicalein, geniposide, total alkaloids, total flavonoids, HPLC total area, ≤1 000 extract were used as indexes, Index values measured standardization, and after the weighted sum of comprehensive evaluation of Y value, Y value is excellent. Results: The comprehensive evaluation of seven indicators Y value to AD + BC maximum. Conclusion: The extract of Coptis chinensis decoction with Coptis chinensis and gardenia, skullcap and cork were combined, and then extract the best combination.