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目的：探讨原发性干燥综合征（pSS）继发肺间质病变（ILD）患者血浆D-二聚体（DD）和纤维蛋白（原）降解产物（FDP）的水平变化及其临床意义。方法检测2011年～2013年住院的42例pSS-ILD患者与同期42例无ILD的pSS患者血浆DD、FDP、血沉（ESR）、C反应蛋白（CRP）、类风湿因子（RF）和免疫球蛋白G（IgG）水平，用两样本t检验和相关性分析进行统计学分析。结果 pSS-ILD组DD、FDP、ESR、CRP、RF和IgG检测结果分别为（864.56±235.82）ng/mL、（6,710.70±564.58）ng/mL、（72.39±12.67）mm/h、（55.94±13.18）mg/L、（54.78±8.02）U/mL和（23.50±4.21） g/L，较无ILD的pSS组（165.00±25.41）ng/mL、（2,760.29±382.46）ng/mL、（45.91±11.35）mm/h、（21.19±12.50） mg/L、（30.98±9.24）U/mL和（12.88±6.04）g/L高，差异有统计学意义（均P＜0.05）。DD和FDP与ESR、CRP均呈直线正相关（r=0.992、0.996和0.923、0.935，均P＜0.01），两者与RF也呈直线正相关（r=0.553，0.509，均P＜0.05）。DD和FDP与IgG无直线正相关（r=0.235，0.361，均P>0.05）。结论 pSS-ILD患者体内存在高凝状态，DD和FDP可作为临床判断pSS继发ILD患者的病情活动的非特异性炎性反应指标。“,”Objective To investigate the clinical value of the plasma level of D-dimer (DD) and fibrinogen degradation products (FDP) in primary Sj?gren’s syndrome (pSS) patients with interstitial lung disease (ILD). Methods Plasma levels of DD, FDP, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), and IgG in 42 patients with pSS-ILD and 42 patients with pSS without ILD admitted to hospital from 2011 to 2013 were measured. Two-sample t-test was used for data analysis by SPSS 19.0 software. Results The plasma levels of DD, FDP, ESR, CRP, RF, and IgG in patients with pSS-ILD were (864.56±235.82) ng/mL, (6,710.70±564.58) ng/mL, (72.39±12.67) mm/h, (55.94±13.18) mg/L, (54.78±8.02) U/mL, and (23.50±4.21) g/L, respectively. These in patients with pSS without ILD were (165.00±25.41) ng/mL, (2,760.29±382.46) ng/mL, (45.91±11.35) mm/h, (21.19±12.50) mg/L, (30.98±9.24) U/mL, and (12.88±6.04) g/L, respectively. The plasma levels in patients with pSS-ILD were higher than those in patients with pSS without ILD (all P<0.05). DD and FDP were positively correlated with ESR (r=0.992 and 0.923, all P<0.01), CRP (r=0.992 and 0.935, all P<0.01), and RF (r=0.553 and 0.509, all P<0.05). Conclusion A hypercoagulable state exists in pSS patients with ILD. DD and FDP can be used as a non-specific inflammatory index in the judgment of disease activity in pSS patients with ILD.