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目的探讨高敏C反应蛋白和纤维蛋白原的变化与颈动脉粥样硬化的关系。方法抽取河南科技大学第三附属医院东方医院接诊的50例颈动脉粥样硬化患者为观察组,选取同期入院检查的45例健康者为对照组,入选患者均采用颈部多普勒超声检查,检测两组患者颈部血管内中膜厚度和斑块情况,并对两组血纤维蛋白原和高敏C反应蛋白浓度进行检测,采用SPSS 17.0统计学软件对两组血清纤维蛋白原、高敏C反应蛋白水平进行t检验。观察组患者按照高敏C反应蛋白、纤维蛋白原水平分为高、中、低水平三组,分析血清高敏C反应蛋白和纤维蛋白原水平在颈动脉粥样硬化患者中的变化及其临床意义。结果观察组患者高敏C反应蛋白(35.29±1.31)mg/L和纤维蛋白原(7.68±1.12)g/L的浓度均高于对照组[高敏C反应蛋白(10.26±1.30)mg/L和纤维蛋白原(3.65±1.02)g/L],组间比较差异有统计学意义(P<0.05);高敏C反应蛋白和纤维蛋白原水平组患者动脉粥样硬化的患病率为66.67%,显著高于中水平组的23.52%和低水平组的6.67%两组,组间比较差异有统计学意义(P<0.05)。结论颈动脉粥样硬化与高敏C反应蛋白和纤维蛋白原的变化存在着密切的关系。
Objective To investigate the relationship between high sensitivity C-reactive protein and fibrinogen and carotid atherosclerosis. Methods Fifty patients with carotid atherosclerosis admitted to Dongfang Hospital of the Third Affiliated Hospital of Henan University of Science and Technology were selected as the observation group and 45 healthy persons admitted in the same period were selected as the control group. All the patients were selected by Doppler ultrasonography . The intima-media thickness and plaque in the neck of the two groups were detected. The concentrations of fibrinogen and high-sensitivity C-reactive protein in the two groups were detected. The levels of serum fibrinogen, high-sensitivity C The level of reactive protein was tested by t test. Patients in the observation group were divided into high, medium and low levels according to the high-sensitivity C-reactive protein and fibrinogen levels. The changes of serum high-sensitivity C-reactive protein and fibrinogen in patients with carotid atherosclerosis were analyzed. Results The concentrations of high sensitive C reactive protein (35.29 ± 1.31) mg / L and fibrinogen (7.68 ± 1.12) g / L in the observation group were higher than those in the control group [high sensitive C reactive protein (10.26 ± 1.30) mg / L and fiber (3.65 ± 1.02) g / L, the difference between the two groups was statistically significant (P <0.05). The prevalence of atherosclerosis was 66.67% in patients with high-sensitivity C-reactive protein and fibrinogen Higher than the middle level group of 23.52% and low level group of 6.67% of the two groups, there was significant difference between the two groups (P <0.05). Conclusion There is a close relationship between carotid atherosclerosis and the changes of high-sensitivity C-reactive protein and fibrinogen.