论文部分内容阅读
本文报道棉酚及其杂质的抗生育作用。实验用叙利亚金黄地鼠,选择8周龄,体重80～100克,具有生育力的雄鼠42只。随机分为4组:(1)对照组(10只);(2)棉酚的杂质组(10只,4mg/kg),(3)纯棉酚组(11只,36mg/kg),(4)不纯棉酚组(11只,40mg/kg,其中含杂质4mg)。临用时药物以5％阿拉伯胶配制成混悬液,各组均按100g 体重灌胃0.1ml,每日一次,连续58天,对照组给予5％阿拉伯胶溶液。各组于停药时处死半数动物,作肉眼检查,肾、肝和睾丸秤重。
This article reports on the antifertility effects of gossypol and its impurities. Experimental Syrian golden hamster, choose 8 weeks old, weighing 80 to 100 grams, 42 male fertility. The rats were randomly divided into 4 groups: (1) control group (10), (2) gossypol impurity group (10, 4mg / kg), (3) gossypol group 4) Gossypol group (11, 40mg / kg, including impurities 4mg). Pro-use drugs to 5% gum arabic formulated as a suspension, each group were gavaged 100ml body weight 0.1ml, once a day for 58 days, the control group was given 5% gum arabic solution. Half of animals were sacrificed at the time of discontinuation for visual inspection, and kidney, liver and testis were weighed.