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严重灼伤及创伤病人的血浆中,纤维蛋白原和纤维蛋白的最终降解产物——D 碎片——的含量可比正常高3～30倍。作者先前的研究表明给动物模型注入提纯的人体 D 碎片将引起明显的血小板减少与呼吸窘迫。为进一步探讨 D 碎片诱发的肺功能不全的机制中,血小板凝集与释放所起的作用,作者设计本实验的日的为:①确定 D 碎片在动物体内是否有增强血小板的功能;②体内有 D 碎片时抗组织胺药苯海拉明是否能抑制血小板功能;③注入 D 碎片后,用测定血小板的丙二酸二醛(MDA)的合成来间接观察前列腺素的释放。
In the plasma of severely burned and traumatized patients, the final degradation products of fibrinogen and fibrin, the content of D fragments, can be 3 to 30 times higher than normal. Previous studies by the authors indicate that injection of purified human D fragments into animal models will cause significant thrombocytopenia and respiratory distress. In order to further investigate the role of platelet aggregation and release in the mechanism of D-fragment-induced pulmonary insufficiency, the authors design the day of the experiment as follows: (1) to determine whether D fragments enhance the function of platelets in animals; (2) Anti-histamine drug diphenhydramine fragments can inhibit platelet function; ③ After the injection of D fragments, the synthesis of malondialdehyde (MDA) to measure the platelet indirectly observed prostaglandin release.