目的：研究硫酸铝钾中的铝对正常及ＡＦ６４Ａ小鼠学习、记忆的影响．方法：被动回避反射仪测避暗潜伏期（ＳＴＬ）；原子吸收分光光度法测血、脑铝；化学发光法测脑乙酰胆碱（ＡＣｈ）；放射化学法测脑胆碱乙酰基转移酶（ＣｈＡＴ）．结果：１ｇ·ｋｇ－１组３０日时，血脑铝升高；６０日伴ＳＴＬ、ＡＣｈ、ＣｈＡＴ分别下降４６４％，８５％，２２６％；９０日ＳＴＬ、ＡＣｈ、ＣｈＡＴ分别下降５００％，１１１％和２７８％．０２５ｇ·ｋｇ－１只有血铝升高．１ｇ·ｋｇ－１使ＡＦ６４Ａ模型小鼠血、脑铝升高，其他无改变．结论：硫酸铝钾１ｇ·ｋｇ－１·ｄ－１６０日使小鼠学习、记忆障碍及胆碱能系统改变 Objective: To study the effect of aluminum aluminum on the learning and memory of normal and AF64A mice. Methods: Passive avoidance reflectometry was used to detect dark latency (STL). Atomic absorption spectrophotometry was used to measure blood and brain aluminum. Chemiluminescence was used to measure acetylcholinesterase (ACh). Radiochemical method was used to measure ChAT. Results: On the 30th day in 1g · kg-1 group, blood brain aluminum increased. On the 60th day, STL, ACh and ChAT decreased by 464%, 85% and 226% respectively. On the 90th, STL, ACh and ChAT Decreased by 500%, 111% and 278% respectively. 0  25g · kg-1 only blood aluminum increased. 1g · kg-1 AF64A model mice blood, cerebral aluminum increased, the other did not change. CONCLUSION: Alzheimer’s disease is associated with changes in memory impairment and cholinergic system at 1 g · kg-1 · d-160 days