《Canad Med Asso J》1983;129(1):14. 临床医师已长期观察到继局灶性脑损伤后的中枢神经系统功能低下,可远远超过病变范围本身,延伸到同侧的全部脑半球或甚至全脑。尽管神经外科医师通常将脑水肿的上述影响归咎于血脑屏障的开放和液体外渗,但神经化学家一直在探索脑代谢中更为特异的和更细小的异常变化。在蒙特利尔神经研究所的2名研究人员正在探索大白鼠脑损伤后一系列复杂的生化变 “Canad Med Asso J” 1983; 129 (1): 14. Clinicians have long observed that central nervous system dysfunction following focal brain injury extends far beyond the extent of the lesion itself to all of the ipsilateral brain Hemisphere or even whole brain. Although neurosurgeons often attribute the above effects of brain edema to the openness of the blood-brain barrier and extravasation of fluids, neurochemists have been exploring more specific and finer abnormalities in brain metabolism. Two researchers at the Montreal Neurological Institute are exploring a series of complex biochemical changes following brain injury in rats