妊娠期高血压疾病(hypertensive disorder complicating pregnancy)是严重危害母婴健康的妊娠期特发性疾病,在我国该病的发病率为5%～10.4%,是导致产妇及新生儿死亡的主要原因之一。对该病的诊断目前主要依靠临床症状。本研究利用SELDI-TOF-MS技术(surface-enhanced laser desorption/ionlzatlon-timeof flight-mass spectrometry)对子痫前期患者分娩前血清蛋白组谱进行研究,期望发现一些特异性蛋白质,为妊娠期高血压疾病的标志蛋白的筛查、鉴定提供理论基础。 Hypertensive disorder complicating pregnancy (GDM) is an idiopathic gestational disease that seriously affects the health of mothers and infants. The incidence of this disease in China is 5% ~ 10.4%, which is the main cause of maternal and neonatal death one. The diagnosis of the disease mainly depends on the clinical symptoms. In this study, we used SELDI-TOF-MS (surface-enhanced laser desorption / ionlzatlon-timeof flight-mass spectrometry) to study the serum proteome profile of preeclampsia before delivery, expecting to find some specific proteins for gestational hypertension Disease logo protein screening, identification provide the theoretical basis.