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Benazeprilat为一新的ACE抑制剂,是Benazepril的活性代谢物。作者在严重左室(LV)功能低下继发局部缺血性心脏病患者中研究了静滴Benazeprilat后LV收缩和舒张功能及神经元介质的变化。 18例严重冠状动脉病患者(男16例,女2例),静滴本品0.3mg(6例)、1mg(6例)、3mg(3例)和10mg(3例)。血流动力学作用静滴本品20分钟后,心率从每分钟78±17减至71±16次(p<0.0003),LV终期舒张压不变,LV收缩压从17.6±2.3降至16.4±2.5 kPa(p<0.0004),峰+dp/dt每秒钟207.3±44.0降
Benazeprilat, a new ACE inhibitor, is the active metabolite of Benazepril. The authors studied LV contractile and diastolic function and changes in neuronal mediators following Benazeprilat infusion in patients with severe ischemic heart disease secondary to left ventricular (LV) impaired function. 18 patients with severe coronary artery disease (16 males and 2 females), intravenous 0.3mg (6 cases), 1mg (6 cases), 3mg (3 cases) and 10mg (3 cases). Hemodynamic Effects After 20 minutes of intravenous infusion, heart rate was reduced from 78 ± 17 min to 71 ± 16 min (p <0.0003), LV end diastolic pressure was unchanged and LV systolic blood pressure decreased from 17.6 ± 2.3 to 16.4 ± 2.5 kPa (p <0.0004), peak + dp / dt decreased 207.3 ± 44.0 per second