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目的评价患者免疫系统损坏程度及高效抗逆转录病毒疗法(HAART)对艾滋病儿童CD4+T淋巴细胞绝对计数的影响,观察药物治疗的效果并采取预防性服药的时机。方法对12例用HAART治疗4～16个月的艾滋病儿童,进行CD4+T淋巴细胞绝对计数,并对其免疫缺损及治疗效果进行初步评估。结果本次共调查12例HIV艾滋病儿童。其中HIV感染者CD4+计数最少为24个/μL,最多为684个/μL,平均266.58个/μL。治疗前男女CD4值没有性别差异,无统计学意义(t=0.035 24,P>0.5)。治疗后,药物对男女CD4值没有性别差异,无统计学意义(t=0.208 54,P>0.5)。经HAART治疗4～16个月后,CD4+T淋巴细胞绝对计数均值平均升高(248.42±101.73)个/mm3。男女性治疗后CD4+细胞明显高于治疗前,,差异有统计学意义(t=3.927 00,P<0.01)平均增长48.24%。结论该人群在感染HIV-1后,处于免疫缺陷期,免疫缺陷早、中晚期的比例分别为16.70%、16.70%、16.70%及50.00%。HAART治疗对艾滋病儿童的治疗效果较能降低各种机会性感染,延长病人生命,提高生活质量,并在一定程度上可以重建和维护免疫功能。建议HIV感染者尽早进行CD4+T淋巴细胞的检测,以便及时进行抗病毒治疗。
Objective To evaluate the extent of damage to the immune system and the effect of highly active antiretroviral therapy (HAART) on the absolute count of CD4 + T lymphocytes in children with AIDS. To observe the effect of drug treatment and to take preventive medication. Methods Totally 12 children with AIDS who were treated with HAART for 4 to 16 months were enrolled in this study. The absolute CD4 + T lymphocyte counts were counted, and their immunodeficiency and therapeutic effects were evaluated. Results A total of 12 HIV / AIDS children were investigated. Among them, HIV-infected patients had CD4 + counts of at least 24 cells / μL, up to 684 cells / μL, with an average of 266.58 cells / μL. Before treatment, there was no significant difference in sex ratio between male and female patients (t = 0.035 24, P> 0.5). After treatment, there was no significant difference in gender, gender and gender (t = 0.208 54, P> 0.5). After 4 to 16 months of treatment with HAART, mean absolute counts of CD4 + T lymphocytes increased by an average of 248.42 ± 101.73 pieces / mm3. The percentage of CD4 + cells in male and female patients after treatment was significantly higher than that before treatment (t = 3.927 00, P <0.01), with an average increase of 48.24%. Conclusions The HIV-1 immunocompromised group is immunodeficient and has immunocompromised early and advanced stages with rates of 16.70%, 16.70%, 16.70% and 50.00%, respectively. HAART treatment of children with AIDS treatment than to reduce a variety of opportunistic infections, prolong the life of patients and improve the quality of life, and to some extent, can rebuild and maintain immune function. It is suggested that CD4 + T lymphocytes be detected as soon as possible in HIV-infected patients so that antiviral treatment can be carried out in time.