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目的:研究香菇多糖注射液对直肠癌根治术后患者纤维蛋白水平及免疫功能的影响。方法:将2010年5月-2014年10月期间在我院接受直肠癌根治术的患者随机分为两组,观察组术后接受香菇多糖联合FOLFOX-4化疗,对照组术后接受FOLFOX-4化疗,观察两组患者化疗过程中的不良反应,测定化疗前后纤维蛋白水平及免疫功能指标。结果:观察组患者在化疗过程中消化道反应、肝功能损伤、骨髓抑制、周围神经毒性、口腔黏膜损伤、脱发的发生率均显著低于对照组(P<0.05);化疗后,对照组患者外周血中CD3~+CD4~+CD8~-细胞、CD3~+CD4~-CD8~+细胞、CD19~+细胞、CD3~-CD56~+细胞的含量以及血清Ig M、Ig A、Ig G、FIB的含量显著低于化疗前(P<0.05),观察组患者外周血中CD3~+CD4~+CD8~-细胞、CD3~+CD4~-CD8~+细胞、CD19~+细胞、CD3~-CD56~+细胞的含量以及血清Ig M、Ig A、Ig G的含量与化疗前无显著性差异(P>0.05),血清FIB含量显著低于化疗前(P<0.05);观察组患者化疗后外周血中CD3~+CD4~+CD8~-细胞、CD3~+CD4~-CD8~+细胞、CD19~+细胞、CD3~-CD56~+细胞的含量以及血清Ig M、Ig A、Ig G、FIB的含量显著高于对照组(P<0.05),血清FIB含量显著低于对照组(P<0.05)。结论:香菇多糖注射液辅助治疗能够减轻直肠癌根治术后FOLFOX-4化疗的毒副作用、改善免疫功能。
Objective: To study the effect of lentinan on the fibrin level and immune function in patients with rectal cancer after radical operation. Methods: The patients undergoing radical resection of rectal cancer in our hospital from May 2010 to October 2014 were randomly divided into two groups. The observation group received lentinan combined with FOLFOX-4 after operation and the control group received FOLFOX-4 Chemotherapy was performed to observe the adverse reactions during the chemotherapy in both groups. The levels of fibrin and immune function before and after chemotherapy were measured. Results: The incidence of digestive tract reaction, liver injury, myelosuppression, peripheral neurotoxicity, oral mucosal injury and hair loss in the observation group were significantly lower than those in the control group (P <0.05). After chemotherapy, the patients in the control group The levels of CD3 ~ + CD4 ~ + CD8 ~ - cells, CD3 ~ + CD4 ~ -CD8 ~ + cells, CD19 ~ + cells and CD3 ~ -CD56 ~ + cells in peripheral blood and serum levels of Ig M, Ig A, Ig G, The levels of CD3 + CD4 + CD8 + cells, CD3 + CD4 + CD8 + cells, CD19 + cells and CD3 + cells in the peripheral blood of patients in the observation group were significantly lower than those before chemotherapy (P <0.05) The content of CD56 ~ + cells and serum Ig M, Ig A, Ig G levels were not significantly different from those before chemotherapy (P> 0.05), and the content of FIB in serum was significantly lower than that before chemotherapy (P <0.05) The levels of CD3 ~ + CD4 ~ + CD8 ~ - cells, CD3 ~ + CD4 ~ -CD8 ~ + cells, CD19 ~ + cells and CD3 ~ -CD56 ~ + cells in peripheral blood and serum levels of Ig M, Ig A, Ig G, FIB content was significantly higher than the control group (P <0.05), serum FIB content was significantly lower than the control group (P <0.05). Conclusion: Lentinan injection adjuvant therapy can reduce the side effects of FOLFOX-4 chemotherapy after radical resection of rectal cancer and improve immune function.