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目的探讨幽门螺杆菌感染对冠心病患者血清生化水平及颈动脉硬化的影响。方法选取150例冠心病患者,所有患者均接受14 C呼气试验检查,将呼气试验阳性患者分为观察组,阴性患者分为对照组。两组患者均检测甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)、血清同型半胱氨酸(HCY)和血清超敏C反应蛋白(hs-CRP)水平,并接受彩色多普勒超声检查颈动脉。观察并比较两组患者血清生化水平及颈动脉情况。结果观察组患者血清TC、LDL-C、HCY和hs-CRP水平显著高于对照组(P<0.05),两组患者血清TG水平比较差异无统计学意义(P>0.05)。观察组患者内膜厚度显著大于对照组(P<0.05),观察组患者不稳定斑块与总斑块例数显著多于对照组(P<0.05),两组患者稳定斑块例数比较差异无统计学意义(P>0.05)。结论冠心病患者感染幽门螺杆菌会影响脂蛋白代谢,激活炎症反应,增加冠心病患者动脉硬化发生的风险,应早期积极干预治疗。
Objective To investigate the influence of Helicobacter pylori infection on serum biochemical level and carotid atherosclerosis in patients with coronary heart disease. Methods 150 cases of coronary heart disease patients were selected, all patients were 14 C breath test, the breath test positive patients were divided into observation group, negative patients were divided into control group. The levels of TG, TC, LDL-C, HCY and hs-CRP in both groups were measured. And underwent color Doppler ultrasound carotid artery. The serum biochemical levels and carotid artery status were observed and compared between the two groups. Results The levels of TC, LDL-C, HCY and hs-CRP in the observation group were significantly higher than those in the control group (P <0.05). There was no significant difference in serum TG levels between the two groups (P> 0.05). The intima thickness in the observation group was significantly larger than that in the control group (P <0.05). The number of unstable plaques and total plaques in the observation group was significantly more than that in the control group (P <0.05), and the number of stable plaques in the two groups was significantly different No statistical significance (P> 0.05). Conclusion Helicobacter pylori infection in patients with coronary heart disease can affect the metabolism of lipoproteins, activate the inflammatory response and increase the risk of atherosclerosis in patients with coronary heart disease, and should be actively treated early.