噻替哌膀胱内灌注可引起尿路刺激症状和溃疡性膀胱炎,但未见有引起增生性膀胱炎的报告,本院遇见1例,报道如下: 患者男性,45岁。1983年4月因膀胱癌在外院行膀胱部分切除术,术后每周50mg噻替哌膀胱内灌注无中断。10天前噻替哌膀胱内灌注后次日出现尿频、尿急、尿痛、血尿,膀胱充盈时下腹部疼痛,门诊治疗未见好转,于1984年1日7日入院。体检:T36℃,P72次/分,R18次/分,腹部无压痛,未及肿块,肝脾于肋缘下未及,肾区无压痛及叩痛。尿常规,红细胞(+++),白细胞(++)蛋白(+)。消炎、止血治疗,上述症状消失后,行膀胱镜检查,镜下见膀胱三角区右半充血、水肿,膀胱右侧壁、顶壁右半侧大片乳头状肿块,无蒂,中心部轻度坏死,右侧输尿管口未见,左侧输尿管口正常。取活 Thiotepa intravesical instillation can cause urinary tract irritation and ulcerative cystitis, but no report of proliferative cystitis was found. One case was found in our hospital and the report was as follows: Male patient, 45 years old. In 1983 April due to bladder cancer in the external hospital bladder partial resection, weekly 50mg thiotepa intravesical perfusion without interruption. Ten days prior to intravesical instillation, urinary frequency, urinary urgency, dysuria, hematuria, and abdominal pain during bladder filling were observed on the next day after intravesical instillation of streptozotocin. Outpatient treatment did not improve, and was admitted on the 1st of January, 1984. Physical examination: T36 ℃, P72 beats / min, R18 beats / min, abdomen no tenderness, no mass, liver and spleen not under the costal margin, kidney area without tenderness and percussion pain. Urine routine, erythrocyte (+++), leukocyte (++) protein (+). Anti-inflammatory, hemostatic treatment, after the above symptoms disappear, cystoscopy, see the right triangle under the microscope congestion, edema, bladder right side wall, the right side of the right side of the large papillary mass, pedicle, mild central necrosis , The right ureteral orifice was not seen, the left ureteral orifice was normal. Take live