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耐甲氧西林葡萄球菌是引起医院内感染的重要致病菌。为了解该菌的耐药情况，进而为临床预防与治疗提供依据，我们对８８株葡萄球菌进行了耐甲氧西林及耐其它１４种常用抗生素和产β－内酰胺酶的测定。结果：耐甲氧西林金黄色葡萄球菌检出率为５６％，耐甲氧西林凝固酶阴性葡萄球菌检出率为４７．６％；耐甲氧西林敏感葡萄球菌对１４种常用抗生素的耐药性及多重耐药性均高于甲氧西林敏感葡萄球菌；产β－内酰胺酶最高的是耐甲氧西林金黄色葡萄球菌，产酶率为９２．９％，最低的是甲氧西林敏感凝固酶阴性葡萄球菌，为３９．４％，说明产酶与耐药之间有一定关系。耐甲氧西林葡萄球菌对万古霉素、呋喃妥因敏感，提示这２种药可作为临床治疗该类菌的首选药物。
Methicillin-resistant Staphylococcus aureus is an important pathogen that causes nosocomial infections. To understand the drug resistance of the bacterium and further provide a basis for clinical prevention and treatment, we tested methicillin-resistant and 14 other commonly used antibiotics against β-lactamases in 88 Staphylococcus aureus strains. Results: The detection rate of methicillin-resistant Staphylococcus aureus was 56%, methicillin-resistant coagulase-negative Staphylococcus aureus was 47.6%, methicillin-resistant Staphylococcus aureus was resistant to 14 commonly used antibiotics And multi-drug resistance were higher than methicillin-sensitive Staphylococcus aureus; the highest β-lactamase production methicillin-resistant Staphylococcus aureus, enzyme yield was 92.9%, the lowest methicillin-sensitive Coagulase negative staphylococcus, 39.4%, indicating that there is a certain relationship between drug resistance and resistance. Methicillin-resistant Staphylococcus aureus to vancomycin, nitrofurantoin sensitive, suggesting that these two drugs can be used as the drug of choice for clinical treatment of such bacteria.