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目的测定COPD患者血浆心钠素(ANF)、肾素活性(PRA)和白三烯C_4(LTC_4)的水平,评价吸氧对上述物质的影响。 对象 试验组:据病史和肺功能检查有不可逆的气道阻塞的证据,COPD诊断明确,23例患者,平均年龄62±12岁,均不伴有左心室疾患、高血压、心律失常,未用过血管扩张剂和利尿剂,无周围水肿,12例曾有右心衰的历史,血钠均大于134mEq/L,血肌酐均小于120mmol/L;对照组:35例健康人(平均年龄30±8岁)测外周静脉血的ANF(ANFV),随机选择12例志愿者(年龄23～62岁)测血浆LTC_4。
Objective To determine the levels of plasma atrial natriuretic peptide (ANF), renin activity (PRA) and leukotriene C_4 (LTC_4) in COPD patients and evaluate the effect of oxygen on these substances. Subjects Subjects: Evidence of irreversible airway obstruction based on medical history and pulmonary function tests, clear diagnosis of COPD, 23 patients, mean age 62 ± 12 years, with no associated left ventricular disease, hypertension, arrhythmia, unused Vasodilators and diuretics, no peripheral edema, history of right heart failure in 12 cases, blood sodium were more than 134mEq / L, serum creatinine were less than 120mmol / L; control group: 35 healthy people (mean age 30 ± 8 years) measured peripheral blood ANF (ANFV), 12 volunteers were randomly selected (age 23 to 62 years old) to measure plasma LTC_4.