先证者女，２７岁，怀孕４次，均在孕２～３月流产。患者表型正常，无特殊病史，孕期无有害物质接触史、病毒感染史和服药史。妇科检查无异常。其丈夫体健，精液检查正常。家系调查：先证者父母非近亲结婚，均健在，其母曾有多次不明原因的孕早期流产史。除先证者及其母亲... The proband was female, 27 years old, pregnant 4 times, both in pregnancy 2 ~ March abortion. Patients with normal phenotype, no special history, no contact with harmful substances during pregnancy, history of viral infection and medication history. No abnormal gynecological examination. Her husband’s health, normal semen check. Pedigree investigation: probands parents non-relatives married, are alive, his mother had many unexplained early pregnancy miscarriage history. Except for the proband and his mother ...