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目的 :讨论幽门螺旋杆菌 (HelicobacterPylori,Hp)感染与胃癌发生的关系及其可能机制。方法 :10 0例经胃镜及病理检查确诊的胃癌患者组成病例组 ,性别相同 ,年龄相差 3岁以内 ,同一检查日期 ,经胃镜及病理检查确诊为慢性浅表性胃炎 10 0例患者作为对照组。病例组 10 0例 ,分早期、进展期和贲门部、非贲门部分别使用快速尿素酶法进行Hp检测、对照组 10 0例亦采用同一方法进行Hp检测 ,统计结果行x2 检验。结果 :Hp感染率在病例组明显高于对照组 (P <0 0 0 5 ) ,早期胃癌Hp感染明显高于对照组 (P <0 0 0 5 ) ,进展期胃癌Hp感染率与对照组无明显差别 ,非贲门部肿瘤患者Hp感染率明显高于对照组 (P <0 0 0 5 ) ,而贲门部肿瘤Hp感染率与对照组相比无明显差别。结论 :Hp感染可能与胃癌发生有关 ,尤其在早期胃癌的发生中起重要作用 ,与非贲门部胃癌关系密切。
Objective: To discuss the relationship between Helicobacter Pylori (Hp) infection and the occurrence of gastric cancer and its possible mechanism. METHODS: A total of 100 patients with gastric cancer diagnosed by gastroscopy and pathological examination were included in the case group. The genders were the same. The age difference was within 3 years. The same examination date was confirmed by gastroscopy and pathological examination. Chronic superficial gastritis was used as a control group. . In the case group of 100 patients, Hp detection was performed using the rapid urease method in the early stage, advanced stage, and the cardia and non-cardia, respectively. The control group was also used in the same method for Hp detection. The statistical result was analyzed by the x2 test. Results: The Hp infection rate was significantly higher in the case group than in the control group (P < 0.05). The Hp infection in early gastric cancer was significantly higher than that in the control group (P <0 05). The Hp infection rate in advanced gastric cancer and the control group were not. Significantly different, non-cardiac cancer patients with Hp infection rate was significantly higher than the control group (P <0 05), and the cardia cancer Hp infection rate compared with the control group there was no significant difference. Conclusion: Hp infection may be related to the occurrence of gastric cancer, especially in the development of early gastric cancer, and has close relationship with non-cardia gastric cancer.