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检测３０例慢性肾功能衰竭（ＣＲＦ）患者血清可溶性白介素２受体（ＳＩＬ－２Ｒ）和外周血Ｔ淋巴细胞亚群，结果表明：ＣＲＦ患者ＳＩＬ－２Ｒ水平显著高于正常对照组（Ｐ＜０．０１），ＣＤ３、ＣＤ４、ＣＤ４／ＣＤ８显著低于正常对照组（Ｐ＜０．０１）；ＳＩＬ－２Ｒ水平与ＣＤ３、ＣＤ４呈负相关，与ＣＤ８呈正相关；ＳＩＬ－２Ｒ与ＢＵＮ、ＳＣｒ呈正相关，ＣＤ３、ＣＤ４与ＢＵＮ、ＳＣｒ呈负相关，ＣＤ８与ＢＵＮ、ＳＣｒ呈正相关。提示：ＣＲＦ患者细胞免疫功能低下；ＳＩＬ－２Ｒ水平与Ｔ淋巴细胞亚群变化有一定关系；ＳＩＬ－２Ｒ水平与Ｔ淋巴细胞亚群变化可作为肾功能恶化的指标。
The levels of serum soluble interleukin 2 receptor (SIL-2R) and peripheral blood T lymphocyte subsets in 30 patients with chronic renal failure (CRF) were measured. The results showed that the levels of SIL-2R in CRF patients were significantly higher than those in normal controls (P <0 (P <0.01). The level of SIL-2R was negatively correlated with CD3 and CD4, and positively correlated with CD8. The expression of SIL-2R was positively correlated with BUN and SCr Correlation, CD3, CD4 and BUN, SCr was negatively correlated, CD8 and BUN, SCr was positively correlated. It is suggested that the cellular immune function is low in patients with CRF; the level of SIL-2R is related to the change of T lymphocyte subsets; the change of SIL-2R level and T lymphocyte subsets may be used as indicators of renal dysfunction.