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为了解日达仙的免疫调节作用 ,选取 18例重症肝炎病人用日达仙 (Tα1)治疗 ,并在治疗前后检测内毒素 (LSP)、肿瘤坏死因子 (TNF)、白细胞介素 2受体 (IL - 2R)、白细胞介素 4(IL - 4)、白细胞介素 6 (IL - 6 )、及T细胞亚群 (CD+ 8CD+ 4)。结果治疗前LSP、TNF、IL - 2R、IL - 6、CD+ 8均增高 (P <0 0 1) ,而IL - 4及CD+ 4降低。经Tα1治疗后LSP、TNF、IL - 2R、IL - 6、CD+ 8均降低 (P <0 0 1) ,而IL - 4和CD+ 4增高。提示Tα1是一种强有力的免疫调节剂 ,它能降低LSP、TNF、IL - 2R、IL - 6、CD+ 8,提升IL - 4水平 ,从而减轻重症肝炎时免疫反应对肝细胞的损伤
In order to understand the immunomodulatory effect of Zadaxin, 18 patients with severe hepatitis were treated with Tα1, and the levels of endotoxin (LSP), tumor necrosis factor (TNF), interleukin 2 receptor IL - 2R, IL - 4, IL - 6, and T cell subsets (CD + 8CD + 4). Results Before treatment, the levels of LSP, TNF, IL - 2R, IL - 6 and CD + 8 increased (P <0.01), while IL - 4 and CD + 4 decreased. After Tα1 treatment, the levels of LSP, TNF, IL - 2R, IL - 6 and CD + 8 were all decreased (P <0.01), while the levels of IL - 4 and CD + 4 increased. It is suggested that Tα1 is a potent immunomodulatory agent that can decrease the levels of IL - 4, LSP, TNF, IL - 2R, IL - 6 and CD + 8 and thus reduce the damage of hepatocytes caused by immune response in severe hepatitis