荞麦Fagopyrum esculentum Moench多酚(BWP)具有改善大鼠空间记忆损害和反复脑缺血造成的细胞凋亡等作用,但作用机理不明。作者研究了BWP对谷氨酸和红藻氨酸致原代培养海马神经元死亡的作用。 BWP混合物制剂含25％多酚,其中儿茶素和表儿茶素的低聚物约占80％、儿茶素0.21％、表儿茶素0.04％、槲皮素0.01％、芦丁0.02％、金丝桃苷0.25％。从Wistar大鼠胚胎的海马组织中分离出原代神经元,培养 Buckwheat Fagopyrum esculentum Moench polyphenols (BWP) has the effects of improving spatial memory impairment in rats and apoptotic cells caused by repeated cerebral ischemia, but the mechanism of action is unknown. The authors studied the effect of BWP on the death of primary cultured hippocampal neurons induced by glutamate and kainic acid. The BWP mixture contains 25% polyphenols, including about 80% oligomers of catechins and epicatechins, 0.21% catechins, 0.04% epicatechins, 0.01% quercetin, 0.02% rutin Hyperin 0.25%. Primary neurons were isolated from the hippocampal tissue of Wistar rat embryos and cultured.