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目的探讨非高密度脂蛋白胆固醇水平与动脉硬化性脑梗塞的关系及其对发病6个月后预后的影响。方法选取急性起病的动脉硬化性脑梗死患者172例为病例组,同时选取同时间在体检中心体检健康者106例为对照组,测定总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇,并计算出非高密度胆固醇水平,分析2组非高密度脂蛋白胆固醇水平情况;病例组发病后6个月根据改良Rankin残障量表(MRS)评分分为预后良好组及预后不良组,利用单因素相关分析及回归法分析2组非高密度脂蛋白胆固醇水平与预后的相关性。结果 (1)病例组非高密度脂蛋白胆固醇水平明显高于对照组(P<0.05);(2)经单因素相关分析显示,非高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平、NIHSS评分、年龄为影响病例组发病6个月时预后的因素。结论非高密度脂蛋白胆固醇水平是动脉硬化性脑梗死患者发生发展的危险因素,可能是动脉硬化性脑梗死患者中远期结局的另一个预测因子
Objective To explore the relationship between non-high-density lipoprotein cholesterol and arteriosclerotic cerebral infarction and its effect on the prognosis after 6 months. Methods A total of 172 patients with acute onset cerebral arterial infarction were selected as the case group. At the same time, 106 healthy subjects were selected as the control group. The levels of total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, The levels of non-HDL cholesterol were calculated, and the levels of non-HDL cholesterol in two groups were analyzed. Six months after the onset of disease, the patients were divided into two groups according to Modified Rankin Disability Scale (MRS): good prognosis group and poor prognosis group. Correlation analysis and regression analysis of two groups of non-high-density lipoprotein cholesterol levels and prognosis. Results (1) The level of non-HDL cholesterol in case group was significantly higher than that in control group (P <0.05). (2) The level of non-HDL cholesterol, LDL cholesterol, NIHSS score , Age is the prognosis factor affecting the case group 6 months after onset. Conclusion The non-HDL cholesterol level is a risk factor for the development of patients with atherosclerosis infarction. It may be another predictor of long-term outcomes in patients with arteriosclerotic cerebral infarction