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目的评估武汉市普通人群戊型病毒性肝炎病毒(戊型肝炎病毒,hepatitis E virus,HEV)感染状况及影响因素。方法采用多阶段随机抽样方法,对抽取的3 890名0~59岁普通人群开展调查与血样采集,应用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)检测抗-HEV IgG,采用χ~2检验、精确二项式公式法与非条件Logistic回归等方法进行统计学分析。结果武汉市0~59岁普通人群抗-HEV IgG标化阳性率为35.01%,男性标化阳性率与女性的差异无统计学意义(χ~2=3.18,P=0.075),随着年龄增长阳性率升高(χ~2=542.32,P<0.001),城区人群标化阳性率高于郊区(χ~2=11.32,P=0.001);18岁以上人群抗-HEV IgG多因素分析显示,男性、年龄较大者(30~59岁)、居住于城区、喜食鱼类的人群感染HEV的风险更高(均有P<0.05)。结论武汉市普通人群HEV感染率较高,男性、年龄较大者(30~59岁)、居住于城区、喜食鱼类的居民是高危人群。
Objective To evaluate the prevalence and influencing factors of hepatitis E virus (HEV) in the general population in Wuhan. Methods A total of 3 890 general population aged 0- 59 years were sampled and collected by multi-stage random sampling method. Anti-HEV IgG was detected by enzyme-linked immunosorbent assay (ELISA) 2 test, accurate binomial formula method and non-conditional Logistic regression method for statistical analysis. Results The positive rate of anti-HEV IgG in the general population from 0 to 59 years old in Wuhan was 35.01%. There was no significant difference between male and female (χ ~ 2 = 3.18, P = 0.075) (Χ ~ 2 = 542.32, P <0.001). The positive rate of urbanization was higher in urban areas than in rural areas (χ ~ 2 = 11.32, P = 0.001) Men, older adults (30-59 years), living in urban areas, had a higher risk of having HEV infection (both P <0.05). Conclusion The prevalence of HEV in the general population is higher in Wuhan. The male, the oldest (30-59 years old), lives in the urban area, and the residents who eat fish are the high-risk groups.