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目的比较由雷贝拉唑、阿莫西林、克拉霉素、左氧氟沙星组成的10d序贯疗法与传统三联疗法根除幽门螺杆菌(Hp)的疗效。方法将经胃镜检查确诊为有明显异常的慢性胃炎和消化性溃疡且Hp阳性的患者193例随机分组,治疗组(102例)方案为前5d雷贝拉唑、阿莫西林,后5d雷贝拉唑、克拉霉素、左氧氟沙星;对照组(91例)三联疗法为雷贝拉唑、阿莫西林、克拉霉素,疗程7d。结果治疗组Hp根除率为96.1%,对照组Hp根除率为84.6%,两组比较差异有统计学意义(P<0.05)。结论以雷贝拉唑、阿莫西林、克拉霉素、左氧氟沙星组成的10d序贯疗法治疗Hp感染具有疗效高、不良反应低、依从性好之特点。
Objective To compare the efficacy of sequential therapy with rabeprazole, amoxicillin, clarithromycin and levofloxacin for 10 days and conventional triple therapy for the eradication of Helicobacter pylori (Hp). Methods A total of 193 patients with chronic gastritis, peptic ulcer and Hp positive diagnosed by gastroscopy were randomly divided into two groups. The treatment group (102 cases) were rabeprazole for the first 5 days, amoxicillin for 5 days, Lapezole, clarithromycin, levofloxacin; control group (91 cases) triple therapy for rabeprazole, amoxicillin, clarithromycin, treatment 7d. Results The eradication rate of Hp in the treatment group was 96.1%, while that in the control group was 84.6%. The difference between the two groups was statistically significant (P <0.05). Conclusion The sequence of rabbits treated with rabeprazole, amoxicillin, clarithromycin and levofloxacin for 10 days has the advantages of high efficacy, low adverse reactions and good compliance.