以过渡金属催化的实现芳基-芳基偶联的反应,尤其是通过手性配体的作用生成具有光学活性的旋转受阻异构体(atropisomer)的反应,越来越受到化学工作者的重视,原因在于某些旋转受阻异构体可作为不对称合成的配体,某些则可转化成具有特定的微环境效应的手性大环化合物。1975年,Kumada等首次以镍催化的偶联反应实现了这类旋转受阻异构体的不对称合成,以α-澳-β-甲基萘(1)与由它衍生的Grignard试剂(2)的偶联反应,制成了光学活性的β,β’-二甲基联萘(3)(图式1)。反应的对映体过量(ee)值按不同的手性配体分别 The transition metal-catalyzed aryl-aryl coupling reaction, especially the reaction of optically active hindered atropisomers by the action of chiral ligands, is increasingly valued by chemists , Because some hindered isomers can act as asymmetric ligands for synthesis and some can be converted into chiral macrocycles with specific microenvironment effects. In 1975, for the first time, Kumada et al. Realized the asymmetric synthesis of such hindered isomers by nickel-catalyzed coupling reaction. The reaction of α-O-β-methylnaphthalene (1) with the Grignard reagent (2) The optically active β, β’-dimethyl binaphthyl (3) was prepared (Scheme 1). The enantiomeric excess (ee) of the reaction depends on the different chiral ligands