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目的探讨老年妇女宫颈病变与人乳头状瘤病毒(HPV)感染的相关性。方法选取2013年1月至2014年12月间在淄博市第一医院妇科接受宫颈检查的311例老年妇女作为研究对象,根据检查结果将其分为正常组(150例)、炎性反应组(80例)、低度鳞状上皮细胞内瘤变组(LSIL组,45例)、高度鳞状上皮细胞内瘤变组(HSIL组,30例)和宫颈癌组(6例)。对各组患者HPV感染率进行检测和比较。结果正常组与炎性反应组患者HPV感染率的差异无统计学意义(X~2=0.21,P>0.05),但均显著低于LSIL组、HSIL组和宫颈癌组,差异均有统计学意义(均P<0.05)。LSIL组患者HPV感染率显著低于HSIL组和宫颈癌组,差异均有统计学意义(X~2=13.55、4.76,均P<0.05)。HSIL组与宫颈癌组患者HPV感染率的差异无统计学意义(X~2=0.42,P>0.05)。Spearman等级相关分析显示,老年妇女宫颈病变与HPV感染率具有相关性,差异有统计学意义(rs=0.68,P<0.05)。结果 HPV感染率与老年妇女宫颈病变类型具有一定的相关性,较高的HPV感染率提示有宫颈癌及相关癌前病变的发生,该指标可作为宫颈癌及癌前病变的辅助筛查指标。
Objective To investigate the relationship between cervical lesions and human papilloma virus (HPV) infection in elderly women. Methods A total of 311 elderly women undergoing gynecological examinations at the First Hospital of Zibo City from January 2013 to December 2014 were selected as study subjects. According to the results of the examination, they were divided into normal group (150 cases), inflammatory reaction group ( 80 cases), low grade squamous cell carcinoma (LSIL group, 45 cases), high grade squamous cell carcinoma (HSIL group, 30 cases) and cervical cancer group (6 cases). The HPV infection rate of each group was tested and compared. Results There was no significant difference in HPV infection rates between normal group and inflammatory reaction group (X ~ 2 = 0.21, P> 0.05), but both were significantly lower than those in LSIL group, HSIL group and cervical cancer group Significance (all P <0.05). The infection rate of HPV in LSIL group was significantly lower than that in HSIL group and cervical cancer group (X ~ 2 = 13.55,4.76, all P <0.05). There was no significant difference in HPV infection rate between HSIL group and cervical cancer group (X ~ 2 = 0.42, P> 0.05). Spearman rank correlation analysis showed that cervical lesions in elderly women and HPV infection rates have a correlation, the difference was statistically significant (rs = 0.68, P <0.05). Results The HPV infection rate was related to the type of cervical lesions in the elderly women. The higher HPV infection rate suggested the presence of cervical cancer and related precancerous lesions, which may serve as a secondary screening index for cervical cancer and precancerous lesions.