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本文对４６例ＮＩＤＤＭ病人（男２５例，女２１例，年龄５１．５±７．５岁）和１６例与之相匹配的健康人测定了ＢＭＣ、ＢＭＤ，血清钙、磷、ＡＫＰ、血糖、ＦＲＭ和胰岛素，尿中钙、肌酐和Ｈｙｐ。结果显示ＮＩＤＤＭ患者不论男、女的ＢＭＣ、ＢＭＤ均显著低于正常对照组，血清钙、磷正常，提示ＮＩＤＤＭ的骨量降低可能不伴有骨软化，而以骨质疏松为特点。ＮＩＤＤＭ组的Ｕｃａ／Ｕｃｒ明显升高（０．２３±０．２１比０．１４±０．０８，Ｐ＜０．０５），并且与血糖和血清果糖胺浓度呈正相关（ｒ＝０．３２和０．４１，Ｐ＜０．０５），提示ＮＩＤＤＭ出现骨量降低与高尿钙有关，而且高血糖引起高尿糖状态所致渗透性利尿很可能是高尿钙的主要原因之一。因此，有效地控制高血糖，将减少尿中钙、磷的丢失并预防ＮＩＤＤＭ患者骨质疏松的发生。本研究还发现ＮＩＤＤＭ患者ＢＭＤ与ＦＢＧ无关（ｒ＝０．１９，Ｐ＞０．０５），与ＦＲＭ呈负相关（ｒ＝－０．２６，Ｐ＜０．０５），与ＩＮＳ呈正相关（ｒ＝０．２９，Ｐ＜０．０５），提示残余的ＩＮＳ分泌量和代谢控制的质量是影响ＮＩＤＤＭ患者骨量的主要因素。所以，本研究认为良好的糖尿病控制，特别是予以适量胰岛素，对ＮＩＤＤＭ患者骨质疏松确?
In this paper, 46 cases of NIDDM patients (25 males and 21 females, age 51.5 ± 7.5 years) and 16 matched healthy people were measured BMC, serum calcium, phosphorus, AKP, blood glucose, FRM and insulin, urinary calcium, creatinine, and Hyp. The results showed that both male and female BMC and BMD of NIDDM patients were significantly lower than that of the normal control group, serum calcium and phosphorus were normal, suggesting that the bone mass loss of NIDDM may not be associated with osteomalacia, but characterized by osteoporosis. Uca / Ucr in NIDDM group was significantly higher (0.23 ± 0.21 vs 0.14 ± 0.08, P <0.05), and positively correlated with plasma glucose and serum fructosamine concentrations (r = 0.32 and 0.41, P <0.05), suggesting that the decrease of bone mass in NIDDM was associated with high urinary calcium, and that hyperuricemia caused by high urine glucose may be one of the main causes of high urinary calcium. Therefore, the effective control of hyperglycemia will reduce the loss of calcium and phosphorus in urine and prevent the occurrence of osteoporosis in NIDDM patients. This study also found that BMD in NIDDM patients was not related to FBG (r = 0.19, P> 0.05), but negatively correlated with FRM (r = -0.26, P <0.05) = 0.29, P <0.05), suggesting that the residual INS secretion and metabolic control quality are the main factors affecting the bone mass of NIDDM patients. Therefore, this study suggests that good diabetes control, especially to the right amount of insulin, osteoporosis in patients with NIDDM indeed?