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目的:观察宽叶缬草对培养的人动脉平滑肌细胞迁移能力的影响。方法:取6月龄引产胎儿主动脉平滑肌细胞进行培养。用BoydenChamber检测细胞迁移能力。结果:与对照组比较,宽叶缬草显著抑制了平滑肌细胞的迁移能力(P<0.01)。结论:在体外培养条件下,宽叶缬草可显著并呈剂量依赖性抑制人血管平滑肌细胞的迁移能力。
Objective: To observe the effects of Valeriana officinalis on the migration of cultured human arterial smooth muscle cells. METHODS: Fetal aorta smooth muscle cells were induced by 6-month-old induction. Boyden Chamber was used to test cell migration ability. RESULTS: Compared with the control group, Valeriana officinalis significantly inhibited the migration of smooth muscle cells (P<0.01). CONCLUSION: In vitro culture condition, G. variegata can significantly and dose-dependently inhibit the migration of human vascular smooth muscle cells.