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内皮祖细胞(endothelial progenitor cells,EPCs)是血管内皮细胞的前体细胞,尤其是骨髓来源的EPCs在心脏修复、临床肢体缺血的治疗、冠状动脉疾病的治疗、脑中风治疗、改善血管移植物通畅率、改善糖尿病患者的血管形成能力、作为基因治疗导向载体和靶细胞及抑制肿瘤血管生成等方面具有广阔的应用前景。细胞因子、炎症因子、激素以及药物等可以通过多种细胞信号传导通路影响EPCs的迁移、分化、增值和凋亡,其中丝裂原活化蛋白酶(MAPK)信号传导通路是近几年国内外研究热点。本文就EPCs的生物功能与MAPK信号传导通路的关系进行了综述。
Endothelial progenitor cells (EPCs) are the precursors of vascular endothelial cells, especially bone marrow-derived EPCs in cardiac repair, treatment of clinical limb ischemia, treatment of coronary artery disease, treatment of stroke, improvement of vascular grafts Patency, improve the ability of angiogenesis in diabetic patients, as a gene therapy-oriented vector and target cells and inhibit tumor angiogenesis has broad application prospects. Cytokines, inflammatory factors, hormones and drugs can affect the migration, differentiation, proliferation and apoptosis of EPCs through a variety of cell signaling pathways, of which the mitogen-activated proteinase (MAPK) signaling pathway is the hotspot in recent years . This review summarizes the relationship between the biological function of EPCs and MAPK signal transduction pathways.