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目的:观察阿托伐他汀治疗颈动脉粥样硬化的疗效。方法:合并颈动脉粥样硬化患者159例随机分为治疗组84例,对照组75例。对照组给予肠溶阿司匹林100 mg/次,1次/d,早餐后口服;治疗组给予阿托伐他汀20 mg/次,1次/d,睡前口服。2组疗程均为4个月。分别于治疗前、后应用彩色多普勒超声检测2组颈动脉内膜-中层厚度及斑块大小,并进行比较。结果:治疗组治疗后颈动脉内膜-中层厚度及斑块大小均较治疗前缩小(P<0.05),2组治疗后比较差异有统计学意义(P<0.05)。结论:阿托伐他汀治疗颈动脉粥样硬化疗效满意。
Objective: To observe the effect of atorvastatin on carotid atherosclerosis. Methods: A total of 159 patients with carotid atherosclerosis were randomly divided into treatment group (n = 84) and control group (n = 75). The control group was given enteric-coated aspirin 100 mg once daily after breakfast, and the treatment group was given atorvastatin 20 mg once daily before bedtime. 2 groups of treatment are 4 months. The carotid artery intima - media thickness and plaque size in the two groups were detected by color Doppler ultrasound before and after treatment respectively and compared. Results: The intima - media thickness and plaque size of the carotid arteries decreased after treatment in the treatment group (P <0.05). There was significant difference between the two groups after treatment (P <0.05). Conclusion: Atorvastatin is effective in treating carotid atherosclerosis.