β-珠蛋白病—镰状细胞病和β-地中海贫血系最常见的遗传性疾病,骨髓移植是治疗该病较肯定的方法,但多数患者缺乏合适的供体,为此本文研究了丁酸盐衍生物对该病胎儿血红蛋白基因表达的影响,期待寻找一种有效的治疗方法。 方法 将镰状细胞贫血和β-地中海贫血患者的红细胞在体外进行培养,培养的红系细胞一组加工酸盐衍生物,另一组不加,筛选有刺激γ-珠蛋白合成活性的丁酸盐衍生物;随后,在母羊妊娠114～118天时切开子宫,将经上述筛选后有活性的衍生 β-globinosis - sickle cell disease and β-thalassemia most common hereditary diseases, bone marrow transplantation is a more affirmative treatment of the disease, but most patients lack the appropriate donor, for this study, butyric acid Salt derivatives of the disease fetal hemoglobin gene expression, looking forward to find an effective treatment. Methods Erythrocytes from patients with sickle cell anemia and β-thalassemia were cultured in vitro. One group of cultured erythroid cells were used to process the acid salt derivatives, and the other group was not added. The cells were selected to stimulate the activity of γ-globin synthesis Salt derivatives; Subsequently, the uterus was excised at 114-118 days of gestation and the active derivative