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采用黄嘌呤氧化酶法测定了２３例脑瘤患者血清锰超氧化物歧化酶（Ｍｎ－ＳＯＤ）的活性。发现：胶质瘤患者血清Ｍｎ－ＳＯＤ活性显著低于脑膜瘤及正常对照组（Ｐ＜０．０１）；脑膜瘤组较正常组稍低但无统计学意义（Ｐ＞０．０５）；胶质瘤术后２周血清Ｍｎ－ＳＯＤ活性较术前明显升高（Ｐ＜０．０１）；而脑膜瘤术后Ｍｎ－ＳＯＤ活性较术前无明显改变；复发性脑胶质瘤血清Ｍｎ－ＳＯＤ活性较正常对照组再次明显降低。提示：血清Ｍｎ－ＳＯＤ可作为鉴别颅内良、恶性肿瘤的辅助指标，并为早期诊断复发性胶质瘤提供帮助，同时可作为手术效果的参考指标。
The activities of serum manganese superoxide dismutase (Mn-SOD) in 23 patients with brain tumor were measured by xanthine oxidase method. It was found that the activity of Mn-SOD in glioma patients was significantly lower than that in meningiomas and normal controls (P <0.01); the meningiomas group was slightly lower than the normal group (P> 0.05) The activity of Mn-SOD in the two-week tumorigenic group was significantly higher than that before the operation (P <0.01), while the activity of Mn-SOD in the meningioma group was not significantly changed after operation. The serum level of Mn- SOD activity again significantly lower than the normal control group. It is suggested that serum Mn-SOD can be used as an auxiliary index to differentiate benign and malignant intracranial tumors and provide help for the early diagnosis of recurrent glioma. At the same time, it can be used as a reference index of operative effect.