论文部分内容阅读
目的系统评价CDKAL1基因rs7756992位点A>G多态性与2型糖尿病(T2DM)易感性的关系。方法制定原始文献的纳入、排除标准及检索策略,通过检索学术期刊全文数据库(CNKI)、万方数据库及EMBASE、PubMed、ScienceDirect等数据库,收集有关CDKAL1基因rs7756992位点A>G多态性与T2DM易感性的病例对照研究,以病例组与对照组CDKAL1基因rs7756992位点各种基因模型的比值比(OR)及其95%置信区间(CI)为效应指标进行meta分析,并根据研究人群种族不同进行亚组分析。结果本研究共纳入15篇文献,T2DM组和对照组病例数分别为24 315例和35 132例。Meta分析显示,CDKAL1基因rs7756992位点A>G多态性与T2DM易感性有关联[等位基因模式(G vs A):OR=1.171,95%CI1.122~1.223,P<0.001;共显性模式(GG vs AA):OR=1.380,95%CI1.258~1.515,P<0.001;共显性模式(AG vs AA):OR=1.131,95%CI 1.089~1.176,P<0.001;显性模式(AG+GG vs AA):OR=1.168,95%CI 1.101~1.240,P<0.001;隐性模式(GG vs AA+AG):OR=1.343,95%CI 1.282~1.405,P<0.001]。亚组分析显示,亚洲人群和白种人群中携带CDKAL1基因rs7756992位点G等位基因的人群发生T2DM的风险增加(P<0.05);而非洲人群中携带CDKAL1基因rs7756992位点G等位基因与A等位基因的人群发生T2DM风险的差异无统计学意义。结论在亚洲人群及白种人群中CDKAL1基因rs7756992位点A>G等位基因的突变可能是T2DM发病的危险因素之一。
Objective To evaluate the relationship between the polymorphism of rs7756992 A> G of CDKAL1 gene and susceptibility to type 2 diabetes mellitus (T2DM). Methods To establish the inclusion, exclusion criteria and search strategies of original documents, and to search the databases of CNKI, EMBASE, PubMed, ScienceDirect and other databases to collect the data of A> G polymorphism of rs7756992 in CDKAL1 gene and T2DM Case-control group and the control group, the odds ratio (OR) and 95% confidence interval (CI) of the rs7756992 locus of CDKAL1 gene were used as the meta-analysis.According to the study population’s race difference Subgroup analysis. Results A total of 15 articles were included in this study, with 24 315 and 35 132 T2DM and control groups, respectively. Meta-analysis showed that the A> G polymorphism of rs7756992 in CDKAL1 gene was associated with susceptibility to T2DM [allele pattern (G vs A): OR = 1.171, 95% CI 1.122-1.223, P <0.001; (GV vs AA): OR = 1.380, 95% CI1.258-1.515, P <0.001; AG vs AA: OR = 1.131, 95% CI 1.089-1.1776, P <0.001; OR = 1.168, 95% CI 1.101-1.240, P <0.001; Recessive mode (GG vs AA + AG): OR = 1.343, 95% CI 1.282-1.405, P <0.001 ]. Subgroup analysis showed that the risk of T2DM was increased in Asian population and Caucasian population with G allele of rs7756992 locus in CDKAL1 gene (P <0.05), while in African population, the G allele of rs7756992 locus carrying CDKAL1 gene was associated with There was no significant difference in the risk of T2DM among A alleles. Conclusion The mutation of A> G allele of rs7756992 in CDKAL1 gene may be one of the risk factors of T2DM in Asian population and Caucasian population.