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急性髓系白血病（ＡＭＬ）Ｍ＿（２ｂ）常伴有ｔ（８：２１）染色体易位，两个染色体重排导致形成ＡＭＬＩ／ＭＴＧ８融合基因，并持续产生融合基因转录本。作者利用逆转录。多聚酶链反应（ＲＴ－ＰＣＲ）扩增ＡＭＬ１／ＭＴＧ８融合基因转录本进行ＡＭＬ－Ｍ＿（２ｂ）微量残留白血病的监测，在１３例完全缓解的患者中，１２例可检出残留白血病细胞。经随诊这１２例中，２例已复发，１例死于强化治疗骨髓抑制期，９例仍持续完全缓解。
Acute myeloid leukemia (AML) M_(2b) is often accompanied by a t(8:21) chromosomal translocation. Two chromosome rearrangements lead to the formation of the AMLI/MTG8 fusion gene and continuous production of fused gene transcripts. The author uses reverse transcription. Polymerase chain reaction (RT-PCR) amplification of AML1/MTG8 fusion gene transcripts was used to monitor AML-M_(2b) minimal residual leukemia. Residual leukemia cells were detected in 12 of 13 complete remission patients. Of the 12 patients followed up, 2 had relapsed, 1 died of intensive therapy for myelosuppression, and 9 cases continued to have complete remission.