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目的探讨乳腺癌X线摄影恶性钙化征象与雌激素受体(ER)、孕激素受体(PR)及人表皮生长因子相关基因(CerbB-2/HER-2/neu)表达、淋巴结转移及肿块大小的相关性。方法回顾分析87例术后病理诊断为乳腺癌患者的乳腺X线摄影胶片,记录乳腺癌钙化情况,记录术后标本肿瘤细胞ER、PR及CerbB-2表达的免疫组化结果、记录术后病理淋巴结转移情况及肿块大小,分析乳腺癌恶性钙化灶与上述因素的关系。结果乳腺癌恶性钙化灶与ER、PR表达、淋巴结转移情况及肿块大小无显著关联性(P>0.05),而乳腺癌恶性钙化灶与CerbB-2的表达有显著关联性(P<0.05)。结论乳腺癌恶性钙化征象与分子生物学指标CerbB-2之间存在一定的关联性。乳腺癌X线摄影从一定程度上反映了癌细胞的生物学行为。
Objective To investigate the relationship between the malignant calcification and the expression of estrogen receptor (PR) and CerbB-2 / HER-2 / neu in patients with breast cancer undergoing radiography, lymph node metastasis and mass Size of relevance. Methods A retrospective analysis of 87 cases of postoperative pathological diagnosis of breast cancer patients mammography film, recording of breast cancer calcification, postoperative specimens of tumor cells ER, PR and CerbB-2 expression of immunohistochemistry, postoperative pathology Lymph node metastasis and tumor size, analysis of malignant calcification of breast cancer and the above factors. Results There was no significant correlation between the malignant calcification of breast cancer and the expression of ER, PR, lymph node metastasis and tumor size (P> 0.05). However, there was a significant correlation between malignant calcification and CerbB-2 expression in breast cancer (P <0.05). Conclusion There is a correlation between malignant calcification and CerbB-2, a molecular marker of breast cancer. Breast cancer radiography to some extent reflects the biological behavior of cancer cells.