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Objective To test Calcium ion(Ca2+) flow at the head and end of outer hair cells(OHCs) in resting state and in response to Nimodipine treatment.Methods Non-invasive micro-test techniques were used to study Ca2+ in isolated OHCs in adult guinea pigs.Results Four types of Ca2+ transport were identified in OHCs on basilar membrane tissue fragments:influx at the head of with efflux at the bottom(type 1):efflux at the head of OHCs with influx at the bottom(type 2);influx at the both head and bottom(type 3);and efflux at the both head and bottom(type 4).However,only type 1 and type 3 of Ca2+ ion transport were detected in the cochlea.We propose that Ca2+ ion transport exists in adult guinea pig cochlear OHCs in resting state and is variable.Ca2 + flow in OHC can be inhibited by Nimodipine in resting state.
Objective To test Calcium ion (Ca2 +) flow at the head and end of outer hair cells (OHCs) in resting state and in response to Nimodipine treatment. Methods Non-invasive micro-test techniques were used to study Ca2 + in isolated OHCs in adult guinea Results of the four types of Ca2 + transport were identified in OHCs on basilar membrane tissue fragments: influx at the head of with efflux at the bottom (type 1): efflux at the head of OHCs with influx at the bottom (type 2); influx at type 2 and type 2 of Ca2 + ion transport were detected in the cochlea. We propose that Ca2 + ion transport exists in Adult guinea pig cochlear OHCs in resting state and is variable. Ca2 + flow in OHC can be inhibited by Nimodipine in resting state.