论文部分内容阅读
目的探讨胃苏颗粒联合铝碳酸镁治疗反流性胃炎的临床疗效。方法选取2015年3月—2016年3月榆林市中医医院收治的反流性胃炎患者80例,随机分为对照组和治疗组,每组各40例。对照组口服铝碳酸镁片,2片/次,3次/d。治疗组在对照组基础上口服胃苏颗粒,3袋/次,3次/d。两组患者均治疗2周。观察两组的临床疗效,比较两组的临床症状、生活质量、血管活性肠肽(VIP)及白细胞介素-6(IL-6)的变化。结果治疗后,对照组和治疗组的总有效率分别为80.00%、95.00%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者临床症状评分和胃食管返流疾病生活质量(GERD-HRQL)评分均显著降低,同组治疗前后差异有统计学意义(P<0.05);且治疗组这些观察指标的降低程度明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清VIP及IL-6水平均显著降低,同组治疗前后差异有统计学意义(P<0.05);且治疗组这些观察指标的降低程度明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论胃苏颗粒联合铝碳酸镁治疗反流性胃炎具有较好的临床疗效,可改善临床症状,降低炎症反应,提高生活质量,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of Weisu granule combined with hydrotalcite in the treatment of reflux gastritis. Methods Eighty patients with reflux gastritis admitted from March 2015 to March 2016 in Yulin Hospital of Traditional Chinese Medicine were randomly divided into control group and treatment group, 40 cases in each group. The control group oral aluminum magnesium carbonate tablets, 2 tablets / time, 3 times / d. Treatment group in the control group based on oral Wei Su particles, 3 bags / time, 3 times / d. Two groups of patients were treated for 2 weeks. The clinical effects of the two groups were observed. The clinical symptoms, quality of life, vasoactive intestinal peptide (VIP) and interleukin-6 (IL-6) in the two groups were compared. Results After treatment, the total effective rates of the control group and the treatment group were 80.00% and 95.00%, respectively, with significant difference between the two groups (P <0.05). After treatment, the scores of clinical symptoms and gastroesophageal reflux disease quality of life (GERD-HRQL) were significantly decreased in both groups, with statistical significance (P <0.05) before and after treatment in the two groups; and the reduction of these indexes in the treatment group The degree was significantly lower than the control group, the difference between the two groups was statistically significant (P <0.05). After treatment, the levels of serum VIP and IL-6 in the two groups were significantly decreased, the difference was statistically significant (P <0.05) before and after treatment in the two groups; and the reduction of these indexes in the treatment group was significantly lower than that in the control group The difference was statistically significant (P <0.05). Conclusion Wei Su particles combined with hydrotalcite treatment of reflux gastritis has good clinical efficacy, can improve clinical symptoms, reduce inflammation, improve quality of life, with a certain clinical application value.