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目的 了解胃癌患者外周血淋巴细胞 (PBL)膜白细胞介素 2受体 (CD2 5)水平的临床意义。方法 用流式细胞仪检测 10 0例正常人和 110例胃癌患者术前PBL中CD2 5%,并进行临床病理分析。结果 正常人PBL中CD2 5%平均为 17 2 4± 5 33,110例胃癌病人PBL中CD2 5%平均为 2 2 4 7± 6 82 ,差异有非常显著性 (P <0 0 1)。胃癌患者PBL中CD2 5%升高与肿瘤发生部位、大体类型、肿瘤大小、分化程度和临床分期均有相关性。结论 检测胃癌患者术前PBL中CD2 5%,可为临床提供病人诊断、免疫治疗及预后评估的参考依据。
Objective To investigate the clinical significance of interleukin 2 receptor (CD25) level in peripheral blood lymphocytes (PBL) in patients with gastric cancer. Methods Flow cytometry was used to detect CD2 5% in preoperative PBL of 100 normal subjects and 110 gastric cancer patients, and the clinicopathological analysis was performed. Results The mean percentage of CD2 5% in normal PBLs was 17 2 4 ± 5 33, and the average percentage of CD2 5% PBLs in PBLs of 210 gastric cancer patients was 22 47 ± 6 82 (P 0 01). The increase of 5% CD2 in PBL of gastric cancer patients was correlated with tumor location, gross type, tumor size, differentiation degree and clinical stage. Conclusion The detection of preoperative CDL CD2 5% in patients with gastric cancer can provide a reference for clinical diagnosis, immunotherapy and prognosis evaluation.