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目的阐述亚胺培南西司他丁钠的药理作用及临床应用、应用中的注意事项等情况,为临床合理使用该药提供参考性意见。方法查阅国内外资料和文献,并结合临床实际工作情况,对相关资料进行分类统计以及整理分析。结果亚胺培南西司他丁钠抗菌谱极广,抗菌活性强,特别适用于多种细菌的联合感染和需氧菌及厌氧菌的混合感染,如腹膜炎、重症肺炎、胰腺炎等,但需注意药物配伍和药动学方面问题。结论亚胺培南西司他丁钠可用于敏感菌所致的各种感染,在一些感染特别是重症感染中应用多且效果好,对于一些危重患者可以在抗感染初期使用以赢取宝贵的抢救时间。
Objective To explain the pharmacological effects and clinical application of imipenem and cilastatin sodium, the precautions in application and so on, so as to provide reference for clinical rational use of this medicine. Methods Access to domestic and foreign information and literature, combined with clinical practice, the classification of relevant data statistics and sorting analysis. Results imipenem cilastatin sodium antibacterial spectrum is very wide, strong antibacterial activity, especially for a variety of bacterial infections and aerobic and anaerobic mixed infections, such as peritonitis, severe pneumonia, pancreatitis, etc., but Pay attention to drug compatibility and pharmacokinetic aspects. Conclusion Imipenem Cilastatin sodium can be used in various infections caused by sensitive bacteria. It is widely used and effective in some infections, especially severe infections. It can be used early in anti-infection in some critically ill patients to win valuable rescue time.