糖尿病视网膜病变 ( diabetic retinopathy,DR)是糖尿病最常见和最严重的并发症之一 ,对 DR发病机制的研究为 DR的药物治疗提供了思路。本文就抑制蛋白非酶糖基化终端产物、多元醇通路、DAG- PKC信号通路 ,抑制细胞因子 ,抗氧化和拮抗粘附分子几方面介绍了 DR的治疗药物及研究思路。 Diabetic retinopathy (DR) is one of the most common and serious complications of diabetes mellitus, and the research on the pathogenesis of DR provides the idea of ​​DR drug therapy. In this paper, we introduced the therapeutic drugs and research ideas of DR on the aspects of inhibiting protein non-enzymatic glycation end products, polyol pathway, DAG-PKC signaling pathway, inhibiting cytokines, antioxidation and antagonizing adhesion molecules.