目的探讨不良孕产史病因。方法采用外周血进行淋巴细胞培养,制备染色体标本、G显带核型分析。结果对1145例就诊患者进行检测,发现染色体异常核型47例,异常率为4.10%;另检出染色体多态性变异89例,检出率为7.77%,其中大Y 87例,小Y 1例,9qhl+2例。结论染色体畸变是不良孕产史的一个重要因素。 Objective To investigate the causes of adverse pregnancy. Methods Peripheral blood was used for lymphocyte culture. Chromosome samples were prepared and G - band karyotype analysis was performed. Results A total of 1145 patients were examined. The abnormality rate of karyotype in 47 cases was 4.10%. Another 89 cases of chromosomal polymorphism were detected, the detection rate was 7.77% For example, 9qhl + 2 cases. Conclusion Chromosomal aberrations are an important factor in the history of adverse pregnancy.