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近年来,一些作者已发表了多篇关于研究慢性阻塞性肺部疾病(COPD)预后的文章,这些研究表明本病多呈慢性进行性并具有相当高的死亡率。本文作者报告用72项指标对129例的 COPD (最初 FEV_1值≤1000ml)患者远期预后的研究情况,并提出了对判断预后有意义的几项指标。在129例患者随访观察中,作者着重研究各项有关肺功能的变化和5年、10年生存率间的关系。肺功能每例每年定期作3～4次,研究项目包括肺活量(VC)、一秒用力呼气量(FEV_1)、最大通气量(MBC)、残气量(RV)、肺总量(TLC)及动脉血气分析。气道阻塞可逆性之试验是用25mg Thiazinamium(抗胆碱能支气管扩张剂)肌注之前及30分钟后分别测定 VC、FEV_1和呼吸功。支气管反应过敏性之试验
In recent years, several authors have published articles on the study of the prognosis of chronic obstructive pulmonary disease (COPD), which shows that the disease is mostly chronic and has a high mortality rate. The authors report the long-term prognosis of 129 patients with COPD (initial FEV 1 value ≤ 1000 mL) using 72 indicators and suggest several indicators that are important in determining prognosis. In a follow-up of 129 patients, the authors focused on the relationship between various changes in lung function and 5-year and 10-year survival rates. Pulmonary function is routinely performed 3 to 4 times a year on a regular basis. The research projects include vital capacity (VC), FEV_1, MBC, RV, TLC, and Arterial blood gas analysis. The test for reversibility of airway obstruction was to measure VC, FEV 1, and work of breathing separately before and after 30 minutes of intramuscular injection of 25 mg of Thiazinamium (anticholinergic bronchodilator). Bronchial allergic reaction test