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目的评估早期高剂量阿托伐他汀对急性脑梗死患者短期功能恢复的影响。方法将42例急性脑梗死患者随机分为A组22例和B组20例;A组患者从入院开始即服用阿托伐他汀治疗(80 mg次/d),直到出院;B组住院期间无阿托伐他汀治疗,出院后开始阿托伐他汀治疗(80 mg次/d)。入院3 d和7 d后采用美国国立卫生院卒中量表(NIHSS)和Rankin修订量表(mRS)评估2组患者神经功能缺损程度。结果与治疗前相比,治疗3 d后A组患者NIHSS评分明显降低,治疗7 d后NIHSS评分进一步降低,且均明显低于B组,差异均有统计学意义(P<0.05)。B组治疗7 d后NIHSS评分低于治疗前,差异有统计学意义(P<0.05)。与B组患者相比,A组患者2级评分和3级评分百分比较高,然而4级评分和5级评分比例较低,差异有统计学意义(P<0.01或P<0.05)。结论早期高剂量阿托伐他汀治疗可改善急性脑梗死患者近期神经功能恢复。
Objective To evaluate the effect of early high-dose atorvastatin on short-term functional recovery in patients with acute cerebral infarction. Methods Forty-two patients with acute cerebral infarction were randomly divided into group A (n = 22) and group B (n = 20). Patients in group A were treated with atorvastatin (80 mg / d) Atorvastatin was given and atorvastatin was started after discharge (80 mg / d). At 3 and 7 days after admission, the degree of neurological deficit in both groups was assessed using the National Institutes of Health Stroke Scale (NIHSS) and the Rankin Revision Scale (mRS). Results Compared with those before treatment, the NIHSS score of group A decreased significantly after 3 days of treatment, and NIHSS score decreased further after 7 days of treatment, both of which were significantly lower than those of group B (P <0.05). The NIHSS score of group B after 7 days of treatment was lower than that before treatment, the difference was statistically significant (P <0.05). Compared with patients in group B, patients in group A had higher 2-level and 3-level scores, however, 4-level and 5-level scores were lower, with significant difference (P <0.01 or P <0.05). Conclusion Early high-dose atorvastatin treatment can improve the recent recovery of neurological function in patients with acute cerebral infarction.